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Am J Nucl Med Mol Imaging 2013;3(2):118-128
Original Article
Evaluation of bone remodeling with 18F-fluoride and correlation with the glucose
metabolism measured by 18F-FDG in lumbar spine with time in an experimental
nude rat model with osteoporosis using dy-namic PET-CT
Caixia Cheng, Christian Heiss, Antonia Dimitrakopoulou-Strauss, P Govindarajan, G Schlewitz, Leyun Pan, Reinhard Schnettler,
Klaus Weber, Ludwig G Strauss
Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany; Department of Trauma
Surgery, Univer-sity Hospital Giessen-Marburg GmbH, Giessen, Germany; Laboratory of Experimental Trauma Surgery,
Justus-Liebig University, Giessen, Germany; Department of Radiopharmaceutical Chemistry, German Cancer Research Center,
Heidelberg, Germany
Received October 29, 2012; Accepted December 18, 2012; Epub March 8, 2013; Published March 18, 2013
Abstract: Rats with osteoporosis were involved by combining ovariectomy (OVX) either with calcium and Vitamin D deficiency diet
(Group D), or with glucocorticoid (dexamethasone) treatment (Group C). In the period of 1-12 months, dynamic PET-CT studies were
performed in three groups of rats including Group D, Group C and the control Group K (sham-operated). Standardized uptake values
(SUVs) were calculated, and a 2-tissue compartmental learning-machine model (calculation of K1-k4, VB and the plasma clearance
of tracer to bone mineral (Ki) as well as a non-compartmental model based on the fractal dimension (FD) was used for quantitative
analysis of both groups. The evaluation of PET data was performed over the lumbar spine. The correlation analysis revealed a
significant linear correlation for certain dPET quantitative parameters and time up to 12 months after induction of osteoporosis.
Based on the 18F-Fluoride data, we noted a significant negative correlation for K1 (the fluoride/hydroxyl exchange) in the Group C and
a significant positive correlation for k3, SUV (bone metabolism) and FD in the Group K. The evaluation of the 18F-FDG data revealed
a significant positive correlation for SUV (glucose metabolism) only in Group C. The correlation between the two tracers revealed
significant results between K1 of 18F-Fluoride and SUV of FDG in Group K as well as between FD of 18F-Fluoride and FDG in Group
D and C and between k3 of 18F-Fluoride and SUV of FDG in Group C. (ajnmmi1210004)
Keywords: dPET-CT, 18F-FDG, 18F-fluoride, osteoporosis
Address correspondence to: Dr. Caixia Cheng, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im
Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Phone: 0049-6221-422501; Fax: 0049-6221-422476; E-mail:
c.cheng@dkfz.de
Original Article
Evaluation of bone remodeling with 18F-fluoride and correlation with the glucose
metabolism measured by 18F-FDG in lumbar spine with time in an experimental
nude rat model with osteoporosis using dy-namic PET-CT
Caixia Cheng, Christian Heiss, Antonia Dimitrakopoulou-Strauss, P Govindarajan, G Schlewitz, Leyun Pan, Reinhard Schnettler,
Klaus Weber, Ludwig G Strauss
Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany; Department of Trauma
Surgery, Univer-sity Hospital Giessen-Marburg GmbH, Giessen, Germany; Laboratory of Experimental Trauma Surgery,
Justus-Liebig University, Giessen, Germany; Department of Radiopharmaceutical Chemistry, German Cancer Research Center,
Heidelberg, Germany
Received October 29, 2012; Accepted December 18, 2012; Epub March 8, 2013; Published March 18, 2013
Abstract: Rats with osteoporosis were involved by combining ovariectomy (OVX) either with calcium and Vitamin D deficiency diet
(Group D), or with glucocorticoid (dexamethasone) treatment (Group C). In the period of 1-12 months, dynamic PET-CT studies were
performed in three groups of rats including Group D, Group C and the control Group K (sham-operated). Standardized uptake values
(SUVs) were calculated, and a 2-tissue compartmental learning-machine model (calculation of K1-k4, VB and the plasma clearance
of tracer to bone mineral (Ki) as well as a non-compartmental model based on the fractal dimension (FD) was used for quantitative
analysis of both groups. The evaluation of PET data was performed over the lumbar spine. The correlation analysis revealed a
significant linear correlation for certain dPET quantitative parameters and time up to 12 months after induction of osteoporosis.
Based on the 18F-Fluoride data, we noted a significant negative correlation for K1 (the fluoride/hydroxyl exchange) in the Group C and
a significant positive correlation for k3, SUV (bone metabolism) and FD in the Group K. The evaluation of the 18F-FDG data revealed
a significant positive correlation for SUV (glucose metabolism) only in Group C. The correlation between the two tracers revealed
significant results between K1 of 18F-Fluoride and SUV of FDG in Group K as well as between FD of 18F-Fluoride and FDG in Group
D and C and between k3 of 18F-Fluoride and SUV of FDG in Group C. (ajnmmi1210004)
Keywords: dPET-CT, 18F-FDG, 18F-fluoride, osteoporosis
Address correspondence to: Dr. Caixia Cheng, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im
Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Phone: 0049-6221-422501; Fax: 0049-6221-422476; E-mail:
c.cheng@dkfz.de
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