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Am J Nucl Med Mol Imaging 2012;2(3):271-272
Invited Perspective
FIAU: From reporter gene imaging to imaging of bacterial proliferation
Otto C Boerman, Peter Laverman, Wim JG Oyen
Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Received June 26, 2012; accepted July 3, 2012; Epub July 20, 2012; Published July 31, 2012
Abstract: The radioiodinated thymidine analogue, FIAU, is a tracer that has been developed for reporter gene, for cells that were
transfected with herpes simplex virus thymidine kinase, HSV-TK. FIAU is also a specific substrate of bacterial TK due to the
homology between viral and bacterial TK. In this issue of AJNMMI (http://www.ajnmmi.us), Pullambhatla et al. reported that the
accumulation of 125I-FIAU in pulmonary infectious foci correlated with the bacterial burden in the lungs. 125I-FIAU could be used to
monitor the efficacy of anti-microbial therapy in mice. Potentially 124I-FIAU PET could be used to discriminate microbial from sterile
inflammation in patients with prosthetic implants. (ajnmmi1206006)
Keywords: Infection, inflammation, reporter gene imaging, positron emission tomography (PET)
Address all correspondence to:
Dr. Otto C Boerman
Department Nuclear Medicine, 756
Radboud University Nijmegen Medical Centre
PO Box 9101 - 6500 HB Nijmegen, The Netherland.
Tel: +31-24-3613813; Fax: +31-24-3618942
E-mail: o.boerman@nucmed.umcn.nl
Invited Perspective
FIAU: From reporter gene imaging to imaging of bacterial proliferation
Otto C Boerman, Peter Laverman, Wim JG Oyen
Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Received June 26, 2012; accepted July 3, 2012; Epub July 20, 2012; Published July 31, 2012
Abstract: The radioiodinated thymidine analogue, FIAU, is a tracer that has been developed for reporter gene, for cells that were
transfected with herpes simplex virus thymidine kinase, HSV-TK. FIAU is also a specific substrate of bacterial TK due to the
homology between viral and bacterial TK. In this issue of AJNMMI (http://www.ajnmmi.us), Pullambhatla et al. reported that the
accumulation of 125I-FIAU in pulmonary infectious foci correlated with the bacterial burden in the lungs. 125I-FIAU could be used to
monitor the efficacy of anti-microbial therapy in mice. Potentially 124I-FIAU PET could be used to discriminate microbial from sterile
inflammation in patients with prosthetic implants. (ajnmmi1206006)
Keywords: Infection, inflammation, reporter gene imaging, positron emission tomography (PET)
Address all correspondence to:
Dr. Otto C Boerman
Department Nuclear Medicine, 756
Radboud University Nijmegen Medical Centre
PO Box 9101 - 6500 HB Nijmegen, The Netherland.
Tel: +31-24-3613813; Fax: +31-24-3618942
E-mail: o.boerman@nucmed.umcn.nl
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