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Am J Nucl Med Mol Imaging 2012;2(4):458-474
Original Article
PET/MR in oncology: an introduction with focus on MR and future perspectives for
hybrid imaging
Svetlana Balyasnikova, Johan Löfgren, Robin de Nijs, Yanna Zamogilnaya, Liselotte Højgaard, Barbara M Fischer
Department of Radiology, The N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, 24, Kashirskoe
Shosse, Moscow, 115478, Russia; Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen
University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
Received June 19, 2012; Accepted July 21, 2012; Epub October 15, 2012; Published October 30, 2012
Abstract: After more than 20 years of research, a fully integrated PET/MR scanner was launched in 2010 enabling simultaneous
acquisition of PET and MR imaging. Currently, no clinical indication for combined PET/MR has been established, however the
expectations are high. In this paper we will discuss some of the challenges inherent in this new technology, but focus on potential
applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to
most readers of this journal; thus this paper aims to provide a short and basic introduction to a number of different MRI techniques,
such as DWI-MR (diffusion weighted imaging MR), DCE-MR (dynamic contrast enhanced MR), MRS (MR spectroscopy) and MR for
attenuation correction of PET. All MR techniques presented in this paper have shown promising results in the treatment of patients
with solid tumors and could be applied together with PET increasing the amount of information about the tissues of interest. The
potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the
research perspectives for the use of PET/MR in the development of new tracers and drugs will be discussed. (ajnmmi1206005).
Keywords: PET/MR, oncology, diagnosis, staging, therapy evaluation, radiotherapy planning, molecular imaging
Address all correspondence to:
Dr. BM Fischer
Department of Clinical Physiology
Nuclear Medicine and PET, Rigshospitalet
Copenhagen University Hospital, Blegdamsvej 9
2100 Copenhagen, Denmark.
E-mail: malene.fischer@rh.regionh.dk
Original Article
PET/MR in oncology: an introduction with focus on MR and future perspectives for
hybrid imaging
Svetlana Balyasnikova, Johan Löfgren, Robin de Nijs, Yanna Zamogilnaya, Liselotte Højgaard, Barbara M Fischer
Department of Radiology, The N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, 24, Kashirskoe
Shosse, Moscow, 115478, Russia; Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen
University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
Received June 19, 2012; Accepted July 21, 2012; Epub October 15, 2012; Published October 30, 2012
Abstract: After more than 20 years of research, a fully integrated PET/MR scanner was launched in 2010 enabling simultaneous
acquisition of PET and MR imaging. Currently, no clinical indication for combined PET/MR has been established, however the
expectations are high. In this paper we will discuss some of the challenges inherent in this new technology, but focus on potential
applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to
most readers of this journal; thus this paper aims to provide a short and basic introduction to a number of different MRI techniques,
such as DWI-MR (diffusion weighted imaging MR), DCE-MR (dynamic contrast enhanced MR), MRS (MR spectroscopy) and MR for
attenuation correction of PET. All MR techniques presented in this paper have shown promising results in the treatment of patients
with solid tumors and could be applied together with PET increasing the amount of information about the tissues of interest. The
potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the
research perspectives for the use of PET/MR in the development of new tracers and drugs will be discussed. (ajnmmi1206005).
Keywords: PET/MR, oncology, diagnosis, staging, therapy evaluation, radiotherapy planning, molecular imaging
Address all correspondence to:
Dr. BM Fischer
Department of Clinical Physiology
Nuclear Medicine and PET, Rigshospitalet
Copenhagen University Hospital, Blegdamsvej 9
2100 Copenhagen, Denmark.
E-mail: malene.fischer@rh.regionh.dk
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