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Am J Nucl Med Mol Imaging 2012;2(2):248-259.
Review Article
Molecular imaging of insulin-like growth factor 1 receptor in cancer
Yin Zhang, Weibo Cai
Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, WI, USA; Department of
Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, WI, USA; University of Wisconsin Carbone
Cancer Center, Madison, WI, USA
Received March 9, 2012; accepted March 22, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: Insulin-like growth factor 1 receptor (IGF1R) plays an important role in proliferation, apoptosis, angiogenesis, and tumor
invasion. Histology and in situ hybridization studies have revealed that IGF1R was significantly up-regulated at the protein and mRNA
level in many types of cancer. Since measuring IGF1R expression with immunohistochemistry has many limitations, non-invasive
imaging of IGF1R can allow for more accurate patient stratification (e.g. selecting the right patient population for IGF1R-targeted
therapy) and more effective monitoring of the therapeutic responses in cancer patients. In this review, we will summarize the current
status of imaging IGF1R expression in cancer, which includes single-photon emission computed tomography, positron emission
tomography, fluorescence, and γ-camera imaging. The four major classes of ligands that have been developed for non-invasive
visualization of IGF1R will be discussed: proteins, antibodies, peptides, and affibodies. To date, molecular imaging of IGF1R
expression is understudied and more research effort is needed in the future. (ajnmmi1203002).
Keywords: Insulin-like growth factor 1 receptor (IGF1R), molecular imaging, peptide nucleic acid (PNA), positron emission
tomography (PET), single-photon emission computed tomography (SPECT), cancer
Address all correspondence to:
Dr. Weibo Cai
Departments of Radiology and Medical Physics
School of Medicine and Public Health, University of Wisconsin-Madison
1111 Highland Ave, Room 7137, Madison, WI 53705-2275, USA.
Tel: 1-608-262-1749; Fax: 1-608-265-0614
E-mail: wcai@uwhealth.org
Review Article
Molecular imaging of insulin-like growth factor 1 receptor in cancer
Yin Zhang, Weibo Cai
Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, WI, USA; Department of
Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, WI, USA; University of Wisconsin Carbone
Cancer Center, Madison, WI, USA
Received March 9, 2012; accepted March 22, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: Insulin-like growth factor 1 receptor (IGF1R) plays an important role in proliferation, apoptosis, angiogenesis, and tumor
invasion. Histology and in situ hybridization studies have revealed that IGF1R was significantly up-regulated at the protein and mRNA
level in many types of cancer. Since measuring IGF1R expression with immunohistochemistry has many limitations, non-invasive
imaging of IGF1R can allow for more accurate patient stratification (e.g. selecting the right patient population for IGF1R-targeted
therapy) and more effective monitoring of the therapeutic responses in cancer patients. In this review, we will summarize the current
status of imaging IGF1R expression in cancer, which includes single-photon emission computed tomography, positron emission
tomography, fluorescence, and γ-camera imaging. The four major classes of ligands that have been developed for non-invasive
visualization of IGF1R will be discussed: proteins, antibodies, peptides, and affibodies. To date, molecular imaging of IGF1R
expression is understudied and more research effort is needed in the future. (ajnmmi1203002).
Keywords: Insulin-like growth factor 1 receptor (IGF1R), molecular imaging, peptide nucleic acid (PNA), positron emission
tomography (PET), single-photon emission computed tomography (SPECT), cancer
Address all correspondence to:
Dr. Weibo Cai
Departments of Radiology and Medical Physics
School of Medicine and Public Health, University of Wisconsin-Madison
1111 Highland Ave, Room 7137, Madison, WI 53705-2275, USA.
Tel: 1-608-262-1749; Fax: 1-608-265-0614
E-mail: wcai@uwhealth.org
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