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Am J Nucl Med Mol Imaging 2012;2(2):242-247.
Original Article
Efficacy of 99mTc-EDDA/HYNIC-TOC SPECT/CT scintigraphy in Graves’
ophthalmopathy
Rong Zhao, Jiang Wang, Jinglan Deng, Weidong Yang, Jing Wang
Department of Nuclear Medicine, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China; Department
of General Surgery, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China; Department of Nuclear
Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, 710032, China
Received March 5, 2012; accepted March 19, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: The aim of this study was to investigate the predictive role of the orbital somatostatin receptor scintigraphy with 99mTc-
EDDA/HYNIC-TOC (99mTc-TOC) to detect clinical stage of Graves’ ophthalmopathy and the response to corticosteroid therapy. The
subjects of the experiment were 46 patients with Graves’ ophthalmopathy (GO) and four volunteers without eye disease or GO as the
normal group (NG). Single photon emission computed tomography (SPECT), computed tomography (CT) and the left and right
lateral position planar imaging of the heads of the all subjects were obtained 4 h after the intravenous injection of 555 MBq of 99mTc-
TOC. The 99mTc-TOC SPECT/CT was repeated 3 months later. 35 (35/46) patients were received corticosteroid therapy
(prednisolone, 10 mg po tid ) for 3 months, however, the other 11 patients as control groups did not receive any treatment. The
treatment effect was evaluated both by the orbital 99mTc-TOC uptake and NOSPECS. A significant decrease in the O/OC ratio was
observed in 22 GO patients between pre- and post-treatment (1.64 ± 0.13 vs. 1.21 ± 0.09, P < 0.05). There were neither significant
difference of the O/OC ratio in 13 GO patients between pre- and post-treatment periods, nor significant difference in the 9 (9/11)
patients before and after three months. Orbital 99mTc-TOC scintigraphy is a feasible technique to estimate the Graves’
ophthalmopathy activity and predict the response to subsequent corticosteroid therapy in GO patients. The technique could be a
useful tool for physicians not familiar with CAS determination. (ajnmmi1203001).
Keywords: Graves’ ophthalmopathy, single photon emission computed tomography (SPECT), somatostatin receptor, 99mTc-TOC
Address all correspondence to:
Dr. Jing Wang
Department of Nuclear Medicine
Xijing Hospital, Fourth Military Medical University
Xi’an, Shaanxi, 710032, China.
Tel: +86-18935913632; Fax: +86-0991-4991757
E-mail: zhaorongweiran@yahoo.com.cn
Original Article
Efficacy of 99mTc-EDDA/HYNIC-TOC SPECT/CT scintigraphy in Graves’
ophthalmopathy
Rong Zhao, Jiang Wang, Jinglan Deng, Weidong Yang, Jing Wang
Department of Nuclear Medicine, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China; Department
of General Surgery, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China; Department of Nuclear
Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, 710032, China
Received March 5, 2012; accepted March 19, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: The aim of this study was to investigate the predictive role of the orbital somatostatin receptor scintigraphy with 99mTc-
EDDA/HYNIC-TOC (99mTc-TOC) to detect clinical stage of Graves’ ophthalmopathy and the response to corticosteroid therapy. The
subjects of the experiment were 46 patients with Graves’ ophthalmopathy (GO) and four volunteers without eye disease or GO as the
normal group (NG). Single photon emission computed tomography (SPECT), computed tomography (CT) and the left and right
lateral position planar imaging of the heads of the all subjects were obtained 4 h after the intravenous injection of 555 MBq of 99mTc-
TOC. The 99mTc-TOC SPECT/CT was repeated 3 months later. 35 (35/46) patients were received corticosteroid therapy
(prednisolone, 10 mg po tid ) for 3 months, however, the other 11 patients as control groups did not receive any treatment. The
treatment effect was evaluated both by the orbital 99mTc-TOC uptake and NOSPECS. A significant decrease in the O/OC ratio was
observed in 22 GO patients between pre- and post-treatment (1.64 ± 0.13 vs. 1.21 ± 0.09, P < 0.05). There were neither significant
difference of the O/OC ratio in 13 GO patients between pre- and post-treatment periods, nor significant difference in the 9 (9/11)
patients before and after three months. Orbital 99mTc-TOC scintigraphy is a feasible technique to estimate the Graves’
ophthalmopathy activity and predict the response to subsequent corticosteroid therapy in GO patients. The technique could be a
useful tool for physicians not familiar with CAS determination. (ajnmmi1203001).
Keywords: Graves’ ophthalmopathy, single photon emission computed tomography (SPECT), somatostatin receptor, 99mTc-TOC
Address all correspondence to:
Dr. Jing Wang
Department of Nuclear Medicine
Xijing Hospital, Fourth Military Medical University
Xi’an, Shaanxi, 710032, China.
Tel: +86-18935913632; Fax: +86-0991-4991757
E-mail: zhaorongweiran@yahoo.com.cn
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