| AJNMMI Copyright © 2011-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA |
Am J Nucl Med Mol Imaging 2012;2(2):136-140.
Original Article
In a “nutshell”: intrinsically radio-labeled quantum dots
Weibo Cai, Hao Hong
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA; University of Wisconsin
Carbone Cancer Center, Madison, WI, USA
Received February 14, 2012; accepted March 1, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: Quantum dots (QDs) have many intriguing properties suitable for biomedical imaging applications. The poor tissue
penetration of optical imaging in general, including those using QDs, has motivated the development of various QD-based dual-
modality imaging agents. In this issue of AJNMMI (http://www.ajnmmi.us), Sun et al. reported the synthesis and in vitro/in vivo
characterization of intrinsically radio-labeled QDs (r-QDs), where 109Cd was incorporated into the core/shell of QDs of various
compositions. These r-QDs emit in the near-infrared range, have long circulation half-life, are quite stable with low cytotoxicity, exhibit
small size and low accumulation in the reticuloendothelial system, and can allow for accurate measurement of their biodistribution in
mice. With these desirable features demonstrated in this study, future development and optimization will further enhance the
biomedical potential of intrinsically radio-labeled QDs. (ajnmmi1201001).
Keywords: Quantum-dots (QDs), nanoparticle, positron emission tomography (PET), single-photon emission computed tomography
(SPECT), near-infrared (NIR), optical imaging
Address all correspondence to:
Weibo Cai, PhD
Departments of Radiology and Medical Physics
University of Wisconsin - Madison
Room 7137, 1111 Highland Ave
Madison, WI 53705-2275, USA.
Phone: 608-262-1749; Fax: 608- 265-0614
Email: wcai@uwhealth.org
Original Article
In a “nutshell”: intrinsically radio-labeled quantum dots
Weibo Cai, Hao Hong
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA; University of Wisconsin
Carbone Cancer Center, Madison, WI, USA
Received February 14, 2012; accepted March 1, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: Quantum dots (QDs) have many intriguing properties suitable for biomedical imaging applications. The poor tissue
penetration of optical imaging in general, including those using QDs, has motivated the development of various QD-based dual-
modality imaging agents. In this issue of AJNMMI (http://www.ajnmmi.us), Sun et al. reported the synthesis and in vitro/in vivo
characterization of intrinsically radio-labeled QDs (r-QDs), where 109Cd was incorporated into the core/shell of QDs of various
compositions. These r-QDs emit in the near-infrared range, have long circulation half-life, are quite stable with low cytotoxicity, exhibit
small size and low accumulation in the reticuloendothelial system, and can allow for accurate measurement of their biodistribution in
mice. With these desirable features demonstrated in this study, future development and optimization will further enhance the
biomedical potential of intrinsically radio-labeled QDs. (ajnmmi1201001).
Keywords: Quantum-dots (QDs), nanoparticle, positron emission tomography (PET), single-photon emission computed tomography
(SPECT), near-infrared (NIR), optical imaging
Address all correspondence to:
Weibo Cai, PhD
Departments of Radiology and Medical Physics
University of Wisconsin - Madison
Room 7137, 1111 Highland Ave
Madison, WI 53705-2275, USA.
Phone: 608-262-1749; Fax: 608- 265-0614
Email: wcai@uwhealth.org
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