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Am J Nucl Med Mol Imaging 2012;2(1):55-76
Review Article
Positron emission tomography (PET) imaging with 18F-based radiotracers
Mian M. Alauddin
Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Received September 27, 2011; accepted October 27, 2011; Epub December 15, 2011; Published January 1, 2012
Abstract: Positron Emission Tomography (PET) is a nuclear medicine imaging technique that is widely used in early detection and
treatment follow up of many diseases, including cancer. This modality requires positron-emitting isotope labeled biomolecules,
which are synthesized prior to perform imaging studies. Fluorine-18 is one of the several isotopes of fluorine that is routinely used in
radiolabeling of biomolecules for PET; because of its positron emitting property and favorable half-life of 109.8 min. The biologically
active molecule most commonly used for PET is 2-deoxy-2-18F-fluoro-β-D-glucose (18F-FDG), an analogue of glucose, for early
detection of tumors. The concentrations of tracer accumulation (PET image) demonstrate the metabolic activity of tissues in terms of
regional glucose metabolism and accumulation. Other tracers are also used in PET to image the tissue concentration. In this review,
information on fluorination and radiofluorination reactions, radiofluorinating agents, and radiolabeling of various compounds and
their application in PET imaging is presented. (ajnmmi1109002).
Keywords: Fluorine-18; positron emission tomography (PET); PET radiopharmaceuticals
Full text PDF
Address all correspondence to:
Mian M. Alauddin, PhD
Department of Experimental Diagnostic Imaging, T8.3895, Box 059
The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Houston, TX 77030
Phone: 713-563-4872
Fax: 713-563-4894
E-mail: alauddin@mdanderson.org
Review Article
Positron emission tomography (PET) imaging with 18F-based radiotracers
Mian M. Alauddin
Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Received September 27, 2011; accepted October 27, 2011; Epub December 15, 2011; Published January 1, 2012
Abstract: Positron Emission Tomography (PET) is a nuclear medicine imaging technique that is widely used in early detection and
treatment follow up of many diseases, including cancer. This modality requires positron-emitting isotope labeled biomolecules,
which are synthesized prior to perform imaging studies. Fluorine-18 is one of the several isotopes of fluorine that is routinely used in
radiolabeling of biomolecules for PET; because of its positron emitting property and favorable half-life of 109.8 min. The biologically
active molecule most commonly used for PET is 2-deoxy-2-18F-fluoro-β-D-glucose (18F-FDG), an analogue of glucose, for early
detection of tumors. The concentrations of tracer accumulation (PET image) demonstrate the metabolic activity of tissues in terms of
regional glucose metabolism and accumulation. Other tracers are also used in PET to image the tissue concentration. In this review,
information on fluorination and radiofluorination reactions, radiofluorinating agents, and radiolabeling of various compounds and
their application in PET imaging is presented. (ajnmmi1109002).
Keywords: Fluorine-18; positron emission tomography (PET); PET radiopharmaceuticals
Full text PDF
Address all correspondence to:
Mian M. Alauddin, PhD
Department of Experimental Diagnostic Imaging, T8.3895, Box 059
The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Houston, TX 77030
Phone: 713-563-4872
Fax: 713-563-4894
E-mail: alauddin@mdanderson.org
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